Conference Program
Preliminary program, minor corrections are possible.
Conference Program
06 October 2024 – Sunday
Satellite event:
Advanced School on Structural Biology and Drug Discovery
09:00 – 10:00
09:00 – 10:00
Registration
10:00 – 10:15
10:00 – 10:15
Introduction: the Pipeline
Organizing Committee
10:15 – 11:00
10:15 – 11:00
Drug target discovery and validation
Andrei Gilep, Institute of bioorganic chemistry, NASB, Belarus
11:00 – 11:45
11:00 – 11:45
Structural studies of translation regulation in prokaryotic and eukaryotic pathogenic microorganisms
Konstantin Usachev, Centre for Integrative Structural Biology, National Research Centre Kurchatov Institute, Russia
11:45 – 12:05
11:45 – 12:05
Coffee Break
12.05 – 12:50
12.05 – 12:50
Advanced applied crystallography on modern synchrotron sources
TBA
12:50 – 13:35
12:50 – 13:35
Development of Cryo-EM and its applications in drug discovery
Eugene Pichkur, National Research Centre Kurchatov Institute, Russia
13:35 – 14:35
13:35 – 14:35
Lunch
14:35 – 15:05
14:35 – 15:05
Structure based drug design
Sergei Evteev, Dukhov Automatics Research Institute, Russia
15:05 – 15:35
15:05 – 15:35
Ligand based drug design
Alexander Malyshev, Dukhov Automatics Research Institute, Russia
15:35 – 16:10
15:35 – 16:10
Computer-aided design of pharmaceutical proteins: ‘physical’ and 'neural network' approaches
Chugunov Anton, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Russia
16:10 – 16:40
16:10 – 16:40
Coffee Break
16:40 – 17:25
16:40 – 17:25
Surface plasmon resonance and drug discovery
Leonid Kaluzhskiy, Institute of Biomedical Chemistry, RAS, Russia
17:25 – 18:10
17:25 – 18:10
Case study of innovative Drug Discovery in Russia
Germes Chilov, JSC "ValentaPharm", Russia
07 October 2024 – Monday
09:30 – 11:00
09:30 – 11:00
Registration and Welcome Coffee, Poster Session 1
11:00 – 11:40
11:00 – 11:40
Keynote lecture:
Analysis of nerve cell activity and ion homeostasis using optosensoric approaches
Piotr Bregestovski, Kazan Medical State University, Russia
11:40 – 12:10
11:40 – 12:10
Research on pangolin coronavirus pathogenesis: implications for COVID prevention and control
Lihua Song, Beijing University of Chemical Technology, China
12:10 –12:40
12:10 –12:40
Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase
Wentong Jiang, National Institute of Biological Sciences, China
12:30 – 14:00
12:30 – 14:00
Lunch
14:00 – 14:40
14:00 – 14:40
Conference Opening Ceremony
14:40 – 15:20
14:40 – 15:20
Keynote lecture:
Cytokines as molecular mediators of immunity and targets for therapy
Sergei Nedospasov, Engelhardt Institute of Molecular Biology, RAS, Russia
15:20 – 15:50
15:20 – 15:50
Protein misfolding, aggregation and seeding – the trigger for neuronal death in Parkinson’s disease?
Plamena Angelova, UCL Queen Square Institute of Neurology, England
15:50 – 16:35
15:50 – 16:35
Coffee Break and Poster Session 1
16:35 – 17:05
16:35 – 17:05
Advances in retinal prosthetisation
Michael Firsov, Sechenov Institute for Evolutionary Physiology and Biochemistry, RAS, Russia
17:05 – 17:45
17:05 – 17:45
Keynote lecture:
Molecular physiology and pathology of vision: rhodopsin
Mikhail Ostrovsky, Lomonosov Moscow State University, Russia
08 October 2024 – Tuesday
09:30 – 10:10
09:30 – 10:10
Keynote lecture:
Structural biology investigation on human bitter taste receptors
Zhi-Jie (James) Liu, iHuman Institute, China (remote)
10:10 – 10:40
10:10 – 10:40
GPCR drug discovery: Rational design of polypharmacology
Jianjun Cheng, iHuman Institute, China (remote)
10:40 – 11:30
10:40 – 11:30
Coffee Break and Poster Session 2
11:30 –12:00
11:30 –12:00
The annotation, classification, structure and database building of chordate olfactory receptors
Suwen Zhao, iHuman Institute, China (remote)
12:00 – 12:40
12:00 – 12:40
Keynote lecture:
Memory self-degradation in Alzheimer’s disease and new opportunities for cognitive neuroprotection
Konstantin Anokhin, Lomonosov Moscow State University, Russia
12:40 – 13:10
12:40 – 13:10
Pathogenic agent of Alzheimer's disease and molecular tools for its neutralization
Sergey Kozin, Engelhardt Institute of molecular biology, RAS, Russia
13:10 – 14:30
13:10 – 14:30
Lunch
14:30 – 15:10
14:30 – 15:10
Keynote lecture:
Structure of the II2-III2-IV2 mitochondrial supercomplex from a parasite reveals a protein inhibitor of complex III
Alexey Amunts, Westlake University, China
15:10 – 15:25
15:10 – 15:25

Optogenetics of lysosomes: monitoring differences in the type and stage of disorders and possible interventions
Nikolay Ilyinsky, Moscow Institute of Physics and Technology, Russia
15:25 – 15:40
15:25 – 15:40

Molecular interactions of promising drugs based on D-enantiomeric peptides with the β-amyloid precursor protein
Ivan Okhrimenko, Moscow Institute of Physics and Technology, Russia
15:40 – 16:30
15:40 – 16:30
Coffee Break and Poster Session 2
Masterclass from the Helicon Company at the foyer
16:30 – 19:00
16:30 – 19:00
Translational Research, Development and Innovation in Biotechnology and Bioeconomics (in Russian)
Andrey Rogachev, MIPT Center for molecular mechanisms/LPR
Valentin Borshchevskiy, MIPT Center for molecular mechanisms
Maxim Ostras, LIFT (Life Improvement by Future Technologies)
Nikita Trofimov, MIPT Business School
Sergey Vakhterov, MIPT Startup Studio
Philipp Maximov, MIPT Biotechnology Center
Maxim Magruk, Geropharm
Mikhail Selyanin, Martinex
09 October 2024 – Wednesday
09:30 – 10:10
09:30 – 10:10
Keynote lecture:
Chemogenetic technologies for metabolism control
Vsevolod Belousov, Federal Center of Brain Research and Neurotechnologies, FMBA , Russia
10:10 – 10:40
10:10 – 10:40
Synchrotron Radiation Facility ‘SKIF’: New Experimental Capabilities for Structural Biology
Yan Zubavichus, Synchrotron Radiation Facility 'SKIF', Russia
10:40 – 11:30
10:40 – 11:30
Coffee Break and Poster Session 3
11:30 –12:10
11:30 –12:10
Keynote lecture:
Arrangements of pre-AD membranes due to Aβ(25-35) peptide
Norbert Kučerka, Joint Institute for Nuclear Research, Russia
11:30 – 12:40
11:30 – 12:40
Structural characterization of biomembrane using synchrotron small-angle X-ray scattering
Na Li, Shanghai Advanced Research Institute, CAS, China
12:40 – 13:10
12:40 – 13:10
Crystal structures of obelin with coelenterazine-v before and after light emission confirm coelenterazine dioxyethanone decomposition through ‘light’ and ‘dark’ pathways
Eugene Vysotski, Institute of Biophysics, SB RAS, Russia
13:10 – 14:30
13:10 – 14:30
Lunch
14:30 – 15:10
14:30 – 15:10
Keynote lecture:
Computational Design of Transmembrane Channels and Beyond
Chunfu Xu, National Institute of Biological Sciences, China
15:10 – 15:40
15:10 – 15:40
Generation of Synthetic Antibodies for CAR T-cell Therapy Development
Dmitri Dormeshkin, Institute of Bioorganic Chemistry, NASB, Belarus
15:40 – 16:10
15:40 – 16:10
Novel nanobodies targeting receptor-binding domains of some relevant viral and bacterial human pathogens
Nikolai Sluchanko, Federal Research Centre ‘Fundamentals of Biotechnology’, RAS, Russia
16:10 – 17:00
16:10 – 17:00
Coffee Break and Poster Session 3
17.00 – 17:30
17.00 – 17:30
SPR analysis of proteins and ligands interaction with target membrane protein embedded in a lipid bilayer
Alexis Ivanov, Institute of Biomedical Chemistry, RAS, Russia
17:30 – 18:00
17:30 – 18:00
Protein dynamics within the Lattice Abelian Higgs model
Alexander Molochkov, Pacific Quantum Center, Far East Federal University, Russia
10 October 2024 – Thursday
09:30 – 10:10
09:30 – 10:10
Keynote lecture:
New molecular tools for scalable mapping and recording of neuronal activity in vivo
Kiryl Piatkevich, Westlake University, China
10:10 – 10:40
10:10 – 10:40
Nano-architecture of the presynaptic active zone in different physiological conditions
Nosov Georgii, Federal Center of Brain Research and Neurotechnologies, FMBA , Russia
10:40 – 11:10
10:40 – 11:10
Thermogenetic control of neuronal circuits in vivo
Oleg Podgorny, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS
11:10 –11:40
11:10 –11:40
Structural basis of TRPA1 channel modulation by Cys-knot spider toxins
Zakhar Shenkarev, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Russia
11:40 – 12:20
11:40 – 12:20
Coffee Break
12:20 – 13:00
12:20 – 13:00
Keynote lecture:
Computational structural biophysics of TRPV ion channels
Roman Efremov, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Russia
13:00 – 13:30
13:00 – 13:30
CAR nucleation as a driving force of biomembrane antigen pattern recognition
Georgy Guria, Medical Research Center for Hematology, Russia
13:30 – 13:45
13:30 – 13:45
Monitoring GPCR conformation with GFP-inspired dyes
Anatolii Belousov, Moscow Institute of Physics and Technology, Russia
13:45 – 14:00
13:45 – 14:00
Engineering of soluble bacteriorhodopsin
Andrey Nikolaev, Moscow Institute of Physics and Technology, Russia
14:00 – 14:30
14:00 – 14:30
Role of Ly6/uPAR proteins in the brain pathology
Ekaterina Lyukmanova, Shenzhen MSU-BIT University, China
14:30 – 16:00
14:30 – 16:00
Lunch
11 October 2024 – Friday
09:30 – 10:00
09:30 – 10:00
DNA architecture in bacteria subjected to various types of stress
Yurii Krupyanskii, Semenov Federal Research Center for Chemical Physics, RAS, Russia
10:00 – 10:40
10:00 – 10:40
Keynote lecture:
Structure, function, and regulation of G protein-coupled receptors
Arun Shukla, Indian Institute of Technology, India (remote)
10:40 – 12:00
10:40 – 12:00
Coffee Break and Poster Session 4 (extended)
12:00 – 12:40
12:00 – 12:40
Keynote lecture:
Inflammaging and longevity within the framework of personalized aging
Claudio Franceschi, University of Bologna, Italy (remote)
12:40 –13:10
12:40 –13:10
Consistency of non-linear dynamics of human aging with a generalized Gompertz-Makeham law
Alexey Golubev, N.N. Petrov National Medical Research Center of Oncology, Russia (remote)
13:10 – 14:30
13:10 – 14:30
Lunch
14:30 – 15:10
14:30 – 15:10
Keynote lecture:
Metabolic diversity of extremophilic prokaryotes: results of
genomic and metagenomic analysis
Elizaveta Bonch-Osmolovskaya, Lomonosov State University, Russia
15:10 – 17:00
15:10 – 17:00
EARLY CAREER RESEARCHER PRESENTATIONS & BEST POSTER AWARDS
Concluding remarks
17:00 – 18:30
17:00 – 18:30
Coffee Break